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Articles (41)
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Effect of pentoxifylline on radiation-induced lung and skin toxicity in rats

Wui-Jin Koh, Keith J. Stelzer, Lanell M. Peterson, Bart L. Staker, William F. Ward, Kenneth J. Russell, Thomas W. Griffin

Journal:

International Journal of Radiation Oncology*Biology*Physics

Année:

1995

Langue:

english

Fichier:

PDF, 759 KB

english, 1995

Diazinones as P2 replacements for pyrazole-based cathepsin S inhibitors

Michael K. Ameriks, Scott D. Bembenek, Matthew T. Burdett, Ingrid C. Choong, James P. Edwards, Damara Gebauer, Yin Gu, Lars Karlsson, Hans E. Purkey, Bart L. Staker, Siquan Sun, Robin L. Thurmond, Jia

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 916 KB

english, 2010

Leveraging structure determination with fragment screening for infectious disease drug targets: MECP synthase fromBurkholderia pseudomallei

Darren W. Begley, Robert C. Hartley, Douglas R. Davies, Thomas E. Edwards, Jess T. Leonard, Jan Abendroth, Courtney A. Burris, Janhavi Bhandari, Peter J. Myler, Bart L. Staker, Lance J. Stewart

Journal:

Journal of Structural and Functional Genomics

Année:

2011

Langue:

english

Fichier:

PDF, 703 KB

english, 2011

X-ray structure determination of the glycine cleavage system protein H ofMycobacterium tuberculosisusing an inverse Compton synchrotron X-ray source

Jan Abendroth, Michael S. McCormick, Thomas E. Edwards, Bart Staker, Roderick Loewen, Martin Gifford, Jeff Rifkin, Chad Mayer, Wenjin Guo, Yang Zhang, Peter Myler, Angela Kelley, Erwin Analau, Stephen

Journal:

Journal of Structural and Functional Genomics

Année:

2010

Langue:

english

Fichier:

PDF, 495 KB

english, 2010

SAD phasing using iodide ions in a high-throughput structural genomics environment

Jan Abendroth, Anna S. Gardberg, John I. Robinson, Jeff S. Christensen, Bart L. Staker, Peter J. Myler, Lance J. Stewart, Thomas E. Edwards

Journal:

Journal of Structural and Functional Genomics

Année:

2011

Langue:

english

Fichier:

PDF, 971 KB

english, 2011

Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety

Burgin, Alex B, Magnusson, Olafur T, Singh, Jasbir, Witte, Pam, Staker, Bart L, Bjornsson, Jon M, Thorsteinsdottir, Margret, Hrafnsdottir, Sigrun, Hagen, Timothy, Kiselyov, Alex S

Journal:

Nature Biotechnology

Année:

2009

Langue:

english

Fichier:

PDF, 955 KB

english, 2009

Structure of Hsp15 reveals a novel RNA-binding motif

Staker, Bart L., Korber, Philipp, Bardwell, James C. A., Saper, Mark A.

Journal:

The EMBO Journal

Année:

2000

Langue:

english

Fichier:

PDF, 757 KB

english, 2000

Structural characterization of a ribose-5-phosphate isomerase B from the pathogenic fungusCoccidioides immitis

Thomas E Edwards, Ariel B Abramov, Eric R Smith, Ruth O Baydo, Jess T Leonard, David J Leibly, Kaitlin B Thompkins, Matthew C Clifton, Anna S Gardberg, Bart L Staker, Wesley C Van Voorhis, Peter J Myl

Journal:

BMC Structural Biology

Année:

2011

Langue:

english

Fichier:

PDF, 651 KB

english, 2011

Structural characterization of Burkholderia pseudomallei adenylate kinase (Adk): Profound asymmetry in the crystal structure of the ‘open’ state

Garry W. Buchko, Howard Robinson, Jan Abendroth, Bart L. Staker, Peter J. Myler

Journal:

Biochemical and Biophysical Research Communications

Année:

2010

Langue:

english

Fichier:

PDF, 432 KB

english, 2010

Analysis of Human Tyrosyl-DNA Phosphodiesterase I Catalytic Residues

Amy C. Raymond, Marc C. Rideout, Bart Staker, Kathryn Hjerrild, Alex B. Burgin Jr

Journal:

Journal of Molecular Biology

Année:

2004

Langue:

english

Fichier:

PDF, 1.14 MB

english, 2004

Mechanisms of Camptothecin Resistance by Human Topoisomerase I Mutations

Jill E Chrencik, Bart L Staker, Alex B Burgin, Philippe Pourquier, Yves Pommier, Lance Stewart, Matthew R Redinbo

Journal:

Journal of Molecular Biology

Année:

2004

Langue:

english

Fichier:

PDF, 2.12 MB

english, 2004

RNA Methylation under Heat Shock Control

Hans Bügl, Eric B. Fauman, Bart L. Staker, Fuzhong Zheng, Sidney R. Kushner, Mark A. Saper, James C.A. Bardwell, Ursula Jakob

Journal:

Molecular Cell

Année:

2000

Langue:

english

Fichier:

PDF, 504 KB

english, 2000

Structures of Three Classes of Anticancer Agents Bound to the Human Topoisomerase I−DNA Covalent Complex

Staker, Bart L., Feese, Michael D., Cushman, Mark, Pommier, Yves, Zembower, David, Stewart, Lance, Burgin, Alex B.

Journal:

Journal of Medicinal Chemistry

Année:

2005

Langue:

english

Fichier:

PDF, 475 KB

english, 2005

Design, Synthesis, and Biological Evaluation of Cytotoxic 11-Alkenylindenoisoquinoline Topoisomerase I Inhibitors and Indenoisoquinoline−Camptothecin Hybrids

Fox, Brian M., Xiao, Xiangshu, Antony, Smitha, Kohlhagen, Glenda, Pommier, Yves, Staker, Bart L., Stewart, Lance, Cushman, Mark

Journal:

Journal of Medicinal Chemistry

Année:

2003

Langue:

english

Fichier:

PDF, 304 KB

english, 2003

Cytidine derivatives as IspF inhibitors of Burkolderia pseudomallei

Zhang, Zheng, Jakkaraju, Sriram, Blain, Joy, Gogol, Kenneth, Zhao, Lei, Hartley, Robert C., Karlsson, Courtney A., Staker, Bart L., Edwards, Thomas E., Stewart, Lance J., Myler, Peter J., Clare, Micha

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2013

Langue:

english

Fichier:

PDF, 1.18 MB

english, 2013

Synthesis and Mechanism of Action Studies of a Series of Norindenoisoquinoline Topoisomerase I Poisons Reveal an Inhibitor with a Flipped Orientation in the Ternary DNA−Enzyme−Inhibitor Complex As Determined by X-ray Crystallographic Analysis

Ioanoviciu, Alexandra, Antony, Smitha, Pommier, Yves, Staker, Bart L., Stewart, Lance, Cushman, Mark

Journal:

Journal of Medicinal Chemistry

Année:

2005

Langue:

english

Fichier:

PDF, 700 KB

english, 2005

Crystal structure and putative substrate identification for the Entamoeba histolytica low molecular weight tyrosine phosphatase

Linford, Alicia S., Jiang, Nona M., Edwards, Thomas E., Sherman, Nicholas E., Van Voorhis, Wesley C., Stewart, Lance J., Myler, Peter J., Staker, Bart L., Petri, William A.

Journal:

Molecular and Biochemical Parasitology

Année:

2014

Langue:

english

Fichier:

PDF, 2.11 MB

english, 2014

DcpS as a Therapeutic Target for Spinal Muscular Atrophy

Singh, Jasbir, Salcius, Michael, Liu, Shin-Wu, Staker, Bart L., Mishra, Rama, Thurmond, John, Michaud, Gregory, Mattoon, Dawn R., Printen, John, Christensen, Jeffery, Bjornsson, Jon Mar, Pollok, Brian

Journal:

ACS Chemical Biology

Année:

2008

Langue:

english

Fichier:

PDF, 1.39 MB

english, 2008

Structure of a CutA1 divalent-cation tolerance protein from Cryptosporidium parvum , the protozoal parasite responsible for cryptosporidiosis

Buchko, Garry W., Abendroth, Jan, Clifton, Matthew C., Robinson, Howard, Zhang, Yanfeng, Hewitt, Stephen N., Staker, Bart L., Edwards, Thomas E., Van Voorhis, Wesley C., Myler, Peter J.

Journal:

Acta Crystallographica Section F Structural Biology Communications

Année:

2015

Langue:

english

Fichier:

PDF, 1.54 MB

english, 2015

Structures of a histidine triad family protein from Entamoeba histolytica bound to sulfate, AMP and GMP

Lorimer, Donald D., Choi, Ryan, Abramov, Ariel, Nakazawa Hewitt, Stephen, Gardberg, Anna S., Van Voorhis, Wesley C., Staker, Bart L., Myler, Peter J., Edwards, Thomas E.

Journal:

Acta Crystallographica Section F Structural Biology Communications

Année:

2015

Langue:

english

Fichier:

PDF, 431 KB

english, 2015

Structure of an ADP-ribosylation factor, ARF1, from Entamoeba histolytica bound to Mg 2+ –GDP

Serbzhinskiy, Dmitry A., Clifton, Matthew C., Sankaran, Banumathi, Staker, Bart L., Edwards, Thomas E., Myler, Peter J.

Journal:

Acta Crystallographica Section F Structural Biology Communications

Année:

2015

Langue:

english

Fichier:

PDF, 1.07 MB

english, 2015

Structure of uridine diphosphate N -acetylglucosamine pyrophosphorylase from Entamoeba histolytica

Edwards, Thomas E., Gardberg, Anna S., Phan, Isabelle Q. H., Zhang, Yang, Staker, Bart L., Myler, Peter J., Lorimer, Donald D.

Journal:

Acta Crystallographica Section F Structural Biology Communications

Année:

2015

Langue:

english

Fichier:

PDF, 1.48 MB

english, 2015

Structures of aspartate aminotransferases from Trypanosoma brucei , Leishmania major and Giardia lamblia

Abendroth, Jan, Choi, Ryan, Wall, Abigail, Clifton, Matthew C., Lukacs, Christine M., Staker, Bart L., Van Voorhis, Wesley, Myler, Peter, Lorimer, Don D., Edwards, Thomas E.

Journal:

Acta Crystallographica Section F Structural Biology Communications

Année:

2015

Langue:

english

Fichier:

PDF, 1.32 MB

english, 2015

Biological and Structural Characterization of a Host-Adapting Amino Acid in Influenza Virus

Yamada, Shinya, Hatta, Masato, Staker, Bart L., Watanabe, Shinji, Imai, Masaki, Shinya, Kyoko, Sakai-Tagawa, Yuko, Ito, Mutsumi, Ozawa, Makoto, Watanabe, Tokiko, Sakabe, Saori, Li, Chengjun, Kim, Jin

Journal:

PLoS Pathogens

Année:

2010

Langue:

english

Fichier:

PDF, 2.13 MB

english, 2010

Structures of prostaglandin F synthase from the protozoa Leishmania major and Trypanosoma cruzi with NADP

Moen, Spencer O., Fairman, James W., Barnes, Steve R., Sullivan, Amy, Nakazawa-Hewitt, Stephen, Van Voorhis, Wesley C., Staker, Bart L., Lorimer, Donald D., Myler, Peter J., Edwards, Thomas E.

Journal:

Acta Crystallographica Section F Structural Biology Communications

Année:

2015

Langue:

english

Fichier:

PDF, 1.34 MB

english, 2015

Recent contributions of structure-based drug design to the development of antibacterial compounds

Staker, Bart L, Buchko, Garry W, Myler, Peter J

Journal:

Current Opinion in Microbiology

Année:

2015

Langue:

english

Fichier:

PDF, 614 KB

english, 2015

Membrane skeletal association and post-translational allosteric regulation of Toxoplasma gondii GAPDH1

Dubey, Rashmi, Staker, Bart L., Foe, Ian T., Bogyo, Matthew, Myler, Peter J., Ngô, Huân M., Gubbels, Marc-Jan

Journal:

Molecular Microbiology

Année:

2016

Langue:

english

Fichier:

PDF, 2.67 MB

english, 2016

Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents

Helgren, Travis R., Chen, Congling, Wangtrakuldee, Phumvadee, Edwards, Thomas E., Staker, Bart L., Abendroth, Jan, Sankaran, Banumathi, Housley, Nicole A., Myler, Peter J., Audia, Jonathon P., Horn, J

Journal:

Bioorganic & Medicinal Chemistry

Année:

2017

Langue:

english

Fichier:

PDF, 1.91 MB

english, 2017

Mycofactocin-associated mycobacterial dehydrogenases with non-exchangeable NAD cofactors

Haft, Daniel H., Pierce, Phillip G., Mayclin, Stephen J., Sullivan, Amy, Gardberg, Anna S., Abendroth, Jan, Begley, Darren W., Phan, Isabelle Q., Staker, Bart L., Myler, Peter J., Marathias, Vasilios

Journal:

Scientific Reports

Année:

2017

Langue:

english

Fichier:

PDF, 1.62 MB

english, 2017

Ligand co-crystallization of aminoacyl-tRNA synthetases from infectious disease organisms

Moen, Spencer O., Edwards, Thomas E., Dranow, David M., Clifton, Matthew C., Sankaran, Banumathi, Van Voorhis, Wesley C., Sharma, Amit, Manoil, Colin, Staker, Bart L., Myler, Peter J., Lorimer, Donald

Journal:

Scientific Reports

Année:

2017

Langue:

english

Fichier:

PDF, 2.21 MB

english, 2017

Mycobacterium tuberculosis Rv3651 is a triple sensor-domain protein

Abendroth, Jan, Frando, Andrew, Phan, Isabelle Q., Staker, Bart L., Myler, Peter J., Edwards, Thomas E., Grundner, Christoph

Journal:

Protein Science

Année:

2017

Langue:

english

Fichier:

PDF, 1.04 MB

english, 2017

The identification of inhibitory compounds of Rickettsia prowazekii methionine aminopeptidase for antibacterial applications

Helgren, Travis R., Seven, Elif S., Chen, Congling, Edwards, Thomas E., Staker, Bart L., Abendroth, Jan, Myler, Peter J., Horn, James R., Hagen, Timothy J.

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2018

Langue:

english

Fichier:

PDF, 1.38 MB

english, 2018

Crystal structure of chorismate mutase from Burkholderia thailandensis

Asojo, Oluwatoyin A., Dranow, David M., Serbzhinskiy, Dmitry, Subramanian, Sandhya, Staker, Bart, Edwards, Thomas E., Myler, Peter J.

Journal:

Acta Crystallographica Section F Structural Biology Communications

Année:

2018

Langue:

english

Fichier:

PDF, 1.11 MB

english, 2018

Structure and analysis of nucleoside diphosphate kinase from Borrelia burgdorferi prepared in a transition-state complex with ADP and vanadate moieties

Dumais, Mitchell, Davies, Douglas R., Lin, Tao, Staker, Bart L., Myler, Peter J., Van Voorhis, Wesley C.

Journal:

Acta Crystallographica Section F Structural Biology Communications

Année:

2018

Langue:

english

Fichier:

PDF, 2.17 MB

english, 2018

Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 Subunit

Armour, Brianna L., Barnes, Steve R., Moen, Spencer O., Smith, Eric, Raymond, Amy C., Fairman, James W., Stewart, Lance J., Staker, Bart L., Begley, Darren W., Edwards, Thomas E., Lorimer, Donald D.

Journal:

Journal of Visualized Experiments

Année:

2013

Langue:

english

Fichier:

PDF, 130 KB

english, 2013

Structure of a Burkholderia pseudomallei Trimeric Autotransporter Adhesin Head

Edwards, Thomas E., Phan, Isabelle, Abendroth, Jan, Dieterich, Shellie H., Masoudi, Amir, Guo, Wenjin, Hewitt, Stephen N., Kelley, Angela, Leibly, David, Brittnacher, Mitch J., Staker, Bart L., Miller

Journal:

PLoS ONE

Année:

2010

Langue:

english

Fichier:

PDF, 1.12 MB

english, 2010

Cloning, expression, purification, crystallization and X-ray diffraction analysis of dihydrodipicolinate synthase from the human pathogenic bacterium Bartonella henselae strain Houston-1 at 2.1 Å resolution

Naqvi, Kubra F., Staker, Bart L., Dobson, Renwick C. J., Serbzhinskiy, Dmitry, Sankaran, Banumathi, Myler, Peter J., Hudson, André O.

Journal:

Acta Crystallographica Section F Structural Biology Communications

Année:

2016

Langue:

english

Fichier:

PDF, 1.33 MB

english, 2016

Cloning, expression, purification, crystallization and X-ray diffraction analysis of dihydrodipicolinate synthase from the human pathogenic bacterium Bartonella henselae strain Houston-1 at 2.1 Å resolution

Naqvi, Kubra F., Staker, Bart L., Dobson, Renwick C. J., Serbzhinskiy, Dmitry, Sankaran, Banumathi, Myler, Peter J., Hudson, André O.

Journal:

Acta Crystallographica Section F Structural Biology Communications

Année:

2016

Fichier:

PDF, 1.33 MB

2016

Structural analysis of CACHE domain of the McpA chemoreceptor from Leptospira interrogans

Santos, Jademilson C., Vieira, MÃ´nica L., Abendroth, Jan, Lin, Tao, Staker, Bart L., Myler, Peter J., Nascimento, Ana Lucia T.O.

Journal:

Biochemical and Biophysical Research Communications

Année:

2020

Fichier:

PDF, 1.81 MB

2020

Identification of P218 as a potent inhibitor of Mycobacterium ulcerans DHFR

Riboldi, Gustavo P., Zigweid, Rachael, Myler, Peter J., Mayclin, Stephen J., CouÃ±ago, Rafael M., Staker, Bart L.

Journal:

RSC Medicinal Chemistry

Année:

2020

Fichier:

PDF, 1.10 MB

2020

[BMJ Publishing Group Ltd Abstracts for the STI & HIV World Congress (Joint Meeting of the 23rd ISSTDR and 20th IUSTI), July 14â17, 2019, Vancouver, Canada - ()] Poster Presentations - P316âStructure-based drug design for neisseria gonorrhoeae, chlamydia trachomatis, and mycoplasma genitalium

Barrett, Kayleigh, Michaels, Samantha, Navaluna, Edelmar, Siddaramaiah, Latha, Wood, Gwendolyn, Phan, Isabelle, Zhang, Zhongsheng, Staker, Bart, Subramanian, Sandhya, Totten, Patricia, Soge, Olusegun,

Fichier:

PDF, 71 KB